Genetic targeting of the amphetamine and methylphenidate-sensitive dopamine transporter: on the path to an animal model of attention-deficit hyperactivity disorder.

@article{Mergy2014GeneticTO,
  title={Genetic targeting of the amphetamine and methylphenidate-sensitive dopamine transporter: on the path to an animal model of attention-deficit hyperactivity disorder.},
  author={Marc A. Mergy and Raajaram Gowrishankar and Gwynne L Davis and Tammy Jessen and J Kelly Wright and Gregg D. Stanwood and Maureen K. Hahn and Randy D. Blakely},
  journal={Neurochemistry international},
  year={2014},
  volume={73},
  pages={56-70}
}
Alterations in dopamine (DA) signaling underlie the most widely held theories of molecular and circuit level perturbations that lead to risk for attention-deficit hyperactivity disorder (ADHD). The DA transporter (DAT), a presynaptic reuptake protein whose activity provides critical support for DA signaling by limiting DA action at pre- and postsynaptic receptors, has been consistently associated with ADHD through pharmacological, behavioral, brain imaging and genetic studies. Currently, the… CONTINUE READING
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