Genetic targeting of relaxin and insulin-like factor 3 receptors in mice.

@article{Kamat2004GeneticTO,
  title={Genetic targeting of relaxin and insulin-like factor 3 receptors in mice.},
  author={Aparna A. Kamat and Shu Zhen Feng and Natalia V. Bogatcheva and Anne Truong and Colin Edward Bishop and Alexander I. Agoulnik},
  journal={Endocrinology},
  year={2004},
  volume={145 10},
  pages={4712-20}
}
Relaxin (RLN) is a small peptide hormone that affects a variety of biological processes. Rln1 knockout mice exhibit abnormal nipple development, prolonged parturition, agerelated pulmonary fibrosis, and abnormalities in the testes and prostate. We describe here RLN receptor Lgr7-deficient mice. Mutant females have grossly underdeveloped nipples and are unable to feed their progeny. Some Lgr7-/- females were unable to deliver their pups. Histological analysis of Lgr7 mutant lung tissues… CONTINUE READING