Genetic targeting of green fluorescent protein to gonadotropin-releasing hormone neurons: characterization of whole-cell electrophysiological properties and morphology.

@article{Suter2000GeneticTO,
  title={Genetic targeting of green fluorescent protein to gonadotropin-releasing hormone neurons: characterization of whole-cell electrophysiological properties and morphology.},
  author={K. J. Suter and Walter J Song and Traci L Sampson and J P Wuarin and Justin T Saunders and F. Edward Dudek and Suzanne M. Moenter},
  journal={Endocrinology},
  year={2000},
  volume={141 1},
  pages={412-9}
}
GnRH neurons form the final common pathway for central control of reproduction, with regulation achieved by changing the pattern of GnRH pulses. To help elucidate the neurobiological mechanisms underlying pulsatile GnRH release, we generated transgenic mice in which the green fluorescent protein (GFP) reporter was genetically targeted to GnRH neurons. The expression of GFP allowed identification of 84-94% of immunofluorescently-detected GnRH neurons. Conversely, over 99.5% of GFP-expressing… CONTINUE READING

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