Genetic targeting of ERK1 suggests a predominant role for ERK2 in murine pain models.

@article{Alter2010GeneticTO,
  title={Genetic targeting of ERK1 suggests a predominant role for ERK2 in murine pain models.},
  author={Benedict J Alter and Chengshui Zhao and Farzana Karim and Gary E. Landreth and Robert W Gereau},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2010},
  volume={30 34},
  pages={11537-47}
}
The extracellular signal-regulated kinase (ERK) isoforms, ERK1 and ERK2, are believed to be key signaling molecules in nociception and nociceptive sensitization. Studies using inhibitors targeting the shared ERK1/2 upstream activator, mitogen-activated protein kinase kinase (MEK), and transgenic mice expressing a dominant-negative form of MEK have established the importance of ERK1/2 signaling. However, these techniques do not discriminate between ERK1 and ERK2. To dissect the function of each… CONTINUE READING