Genetic syndromes of severe insulin resistance.

@article{Melvin2018GeneticSO,
  title={Genetic syndromes of severe insulin resistance.},
  author={A. Melvin and Stephen O'Rahilly and David B Savage},
  journal={Current opinion in genetics & development},
  year={2018},
  volume={50},
  pages={
          60-67
        }
}
Insulin resistance underpins the link between obesity and most of its associated metabolic disorders including type 2 diabetes, fatty liver disease, dyslipidaemia and cardiovascular disease. Despite its importance and extensive scientific endeavour, its precise molecular pathogenesis remains unclear. Monogenic syndromes of extreme insulin resistance, whilst rare in themselves, can provide unique insights into the pathogenesis of human insulin resistance. Severe insulin resistance syndromes are… CONTINUE READING

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