Genetic susceptibility to non-polyposis colorectal cancer.

  title={Genetic susceptibility to non-polyposis colorectal cancer.},
  author={Henry T. Lynch and Albert de la Chapelle},
  journal={Journal of medical genetics},
  volume={36 11},
Familial colorectal cancer (CRC) is a major public health problem by virtue of its relatively high frequency. Some 15-20% of all CRCs are familial. Among these, familial adenomatous polyposis (FAP), caused by germline mutations in the APC gene, accounts for less than 1%. Hereditary non-polyposis colorectal cancer (HNPCC), also called Lynch syndrome, accounts for approximately 5-8% of all CRC patients. Among these, some 3% are mutation positive, that is, caused by germline mutations in the DNA… CONTINUE READING
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