Genetic susceptibility to male infertility: news from genome‐wide association studies

  title={Genetic susceptibility to male infertility: news from genome‐wide association studies},
  author={K. I. Aston},
  • K. I. Aston
  • Published 2014
  • Biology, Medicine
  • Andrology
  • A thorough understanding of the genetic basis of male infertility has eluded researchers in spite of significant efforts to identify novel genetic causes of the disease, particularly over the past decade. Approximately half of male factor infertility cases have no known cause; however, it is likely that the majority of idiopathic male factor infertility cases have some unidentified genetic basis. Well‐established genetic causes of male infertility are limited to Y chromosome microdeletions and… CONTINUE READING
    Male Reproductive Disorders and Fertility Trends: Influences of Environment and Genetic Susceptibility.
    • 323
    • PDF
    Single gene defects leading to sperm quantitative anomalies
    • 26
    • PDF


    Publications referenced by this paper.
    Genetics of human male infertility.
    • 275
    • PDF
    A genome-wide association study of men with symptoms of testicular dysgenesis syndrome and its network biology interpretation
    • 86
    • Highly Influential
    • PDF
    Genome-wide association study identifies candidate genes for male fertility traits in humans.
    • 102
    High Resolution X Chromosome-Specific Array-CGH Detects New CNVs in Infertile Males
    • 66
    Array comparative genomic hybridization in male infertility.
    • 39
    • PDF
    Human Spermatogenic Failure Purges Deleterious Mutation Load from the Autosomes and Both Sex Chromosomes, including the Gene DMRT1
    • 98
    • PDF
    Population stratification and spurious allelic association
    • 1,150
    • PDF