Genetic susceptibility to hypertension-induced renal damage in the rat. Evidence based on kidney-specific genome transfer.

@article{Churchill1997GeneticST,
  title={Genetic susceptibility to hypertension-induced renal damage in the rat. Evidence based on kidney-specific genome transfer.},
  author={Paul C Churchill and Monique C Churchill and Anil K. Bidani and Karen A. Griffin and Maria Picken and Michal Pravenec and Vladim{\'i}r Křen and E M St Lezin and Jun Wang and Ning Wang and Theodore W. Kurtz},
  journal={The Journal of clinical investigation},
  year={1997},
  volume={100 6},
  pages={1373-82}
}
To test the hypothesis that genetic factors can determine susceptibility to hypertension-induced renal damage, we derived an experimental animal model in which two genetically different yet histocompatible kidneys are chronically and simultaneously exposed to the same blood pressure profile and metabolic environment within the same host. Kidneys from… CONTINUE READING