Genetic susceptibility to heroin addiction: a candidate gene association study.

  title={Genetic susceptibility to heroin addiction: a candidate gene association study.},
  author={Orna Levran and Douglas Londono and Kirrily O'Hara and David A. Nielsen and Einat Peles and John Rotrosen and Paul P. Casadonte and Shirley Linzy and Matthew Randesi and J{\"u}rg Ott and Maria Adelson and Mary Jeanne Kreek},
  journal={Genes, brain, and behavior},
  volume={7 7},
Heroin addiction is a chronic complex disease with a substantial genetic contribution. This study was designed to identify genetic variants that are associated with susceptibility to develop heroin addiction by analyzing 1350 variants in 130 candidate genes. All subjects had Caucasian ancestry. The sample consisted of 412 former severe heroin addicts in methadone treatment, and 184 healthy controls with no history of drug abuse. Nine variants, in six genes, showed the lowest nominal P values in… CONTINUE READING
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