Genetic susceptibility to diclofenac-induced hepatotoxicity: contribution of UGT2B7, CYP2C8, and ABCC2 genotypes.

@article{Daly2007GeneticST,
  title={Genetic susceptibility to diclofenac-induced hepatotoxicity: contribution of UGT2B7, CYP2C8, and ABCC2 genotypes.},
  author={Ann K Daly and Guruprasad P Aithal and Julian B. S. Leathart and Richard A Swainsbury and Tarana Singh Dang and Christopher Paul Day},
  journal={Gastroenterology},
  year={2007},
  volume={132 1},
  pages={272-81}
}
BACKGROUND & AIMS Diclofenac is a widely used nonsteroidal anti-inflammatory drug and is among the most common drugs causing idiosyncratic hepatotoxicity in several recent series with up to 20% mortality in jaundiced subjects. We hypothesized that susceptibility to hepatotoxicity would be associated with genetic polymorphisms in the genes encoding the enzymes UGT2B7 and CYP2C8, which determine the formation of reactive diclofenac metabolites and in ABCC2 encoding the transporter MRP2… CONTINUE READING

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