Genetic susceptibility to diabetes and long-term improvement of insulin resistance and β cell function during weight loss: the Preventing Overweight Using Novel Dietary Strategies (POUNDS LOST) trial.

@article{Huang2016GeneticST,
  title={Genetic susceptibility to diabetes and long-term improvement of insulin resistance and β cell function during weight loss: the Preventing Overweight Using Novel Dietary Strategies (POUNDS LOST) trial.},
  author={Tao Huang and Sylvia H. Ley and Yan Zheng and Tiange Wang and George A. Bray and Frank M. Sacks and Lu Qi},
  journal={The American journal of clinical nutrition},
  year={2016},
  volume={104 1},
  pages={198-204}
}
BACKGROUND Diet interventions have shown effectiveness in improving diabetes risk factors; however, little is known about whether the effects of diet intervention are different according to genetic susceptibility. OBJECTIVE We examined interactions between weight-loss diets and the genetic risk score (GRS) for diabetes on 2-y changes in markers of insulin resistance and β cell function in a randomized controlled trial. DESIGN Data from the Preventing Overweight Using Novel Dietary… CONTINUE READING
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