Genetic susceptibility to carbamazepine-induced cutaneous adverse drug reactions

@article{Hung2006GeneticST,
  title={Genetic susceptibility to carbamazepine-induced cutaneous adverse drug reactions},
  author={S. Hung and Wen-Hung Chung and Shiou-Hwa Jee and W. Chen and Y. Chang and W. Lee and S. Hu and Meng-Tse Wu and G. Chen and T. Wong and Pa-Fan Hsiao and Wei-Hsuan Chen and Han-Yu Shih and Wu-Hsiang Fang and C. Wei and Yi-Hui Lou and Yau-Li Huang and J. Lin and Y. Chen},
  journal={Pharmacogenetics and Genomics},
  year={2006},
  volume={16},
  pages={297-306}
}
  • S. Hung, Wen-Hung Chung, +16 authors Y. Chen
  • Published 2006
  • Medicine
  • Pharmacogenetics and Genomics
  • The anticonvulsant carbamazepine (CBZ) frequently causes cutaneous adverse drug reactions (cADRs), including maculopapular eruption (MPE), hypersensitivity syndrome (HSS), Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). We reported that SJS/TEN caused by CBZ is strongly associated with the HLA-B*1502 gene in Han Chinese. Here, we extended our genetic study to different types of CBZ-cADRs (91 patients, including 60 patients with SJS/TEN, 13 patients with hypersensitivity… CONTINUE READING
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