Genetic susceptibility to Leishmania: IL-12 responsiveness in TH1 cell development.

@article{Gler1996GeneticST,
  title={Genetic susceptibility to Leishmania: IL-12 responsiveness in TH1 cell development.},
  author={Mehmet L. G{\"u}ler and James D. Gorham and C. Samuel Hsieh and Aaron J. Mackey and R. Grant Steen and William F. Dietrich and Kenneth M Murphy},
  journal={Science},
  year={1996},
  volume={271 5251},
  pages={984-7}
}
The genetic background of T lymphocytes influences development of the T helper (TH) phenotype, resulting in either resistance or susceptibility of certain mouse strains to pathogens such as Leishmania major. With an in vitro model system, a difference in maintenance of responsiveness of T cells to interleukin-12 (IL-12) was detected between BALB/c and B10.D2 mice. Although naive T cells from both strains initially responded to IL-12, BALB/c T cells lost IL-12 responsiveness after stimulation… CONTINUE READING