Genetic susceptibility testing for breast and ovarian cancer: a progress report.

@article{Biesecker1997GeneticST,
  title={Genetic susceptibility testing for breast and ovarian cancer: a progress report.},
  author={Barbara B Biesecker and Lawrence C. Brody},
  journal={Journal of the American Medical Women's Association},
  year={1997},
  volume={52 1},
  pages={22-7}
}
The recent identification of genes that predispose their carriers to breast and ovarian cancer promises to shed light on the biology of cancer susceptibility. Individuals with mutations in the BRCA1 gene on chromosome 17 and the BRCA2 gene on chromosome 13 have four to eight times the risk of developing breast cancer as women in the general population. The many mutations that have been identified in both genes are predicted to produce a truncated, presumably nonfunctional, protein. Individuals… CONTINUE READING