Genetic susceptibility of childhood type 1 diabetes mellitus in Japan.

@article{Sugihara2012GeneticSO,
  title={Genetic susceptibility of childhood type 1 diabetes mellitus in Japan.},
  author={Shigetaka Sugihara},
  journal={Pediatric endocrinology reviews : PER},
  year={2012},
  volume={10 Suppl 1},
  pages={62-71}
}
Most cases of type 1 diabetes mellitus (T1DM) are caused by an autoimmune reaction, involving genetic and environmental factors, which ultimately disrupt insulin-producing pancreatic beta cells. Several genes, including those encoding human leukocyte antigen (HLA) class II (IDDM1 locus), insulin (IDDM2 locus), and cytotoxic T lymphocyte antigen (CTLA) 4 (IDDM12 locus), are involved in this process. In this paper, I review the studies of Japanese patients with childhood type 1A diabetes mellitus… CONTINUE READING