Genetic susceptibility and transmission factors in scrapie: detailed analysis of an epidemic in a closed flock of Romanov

@article{Elsen1999GeneticSA,
  title={Genetic susceptibility and transmission factors in scrapie: detailed analysis of an epidemic in a closed flock of Romanov},
  author={J.-M. Elsen and Y. Amigues and F. Schelcher and V. Ducrocq and O. Andreoletti and F. Eychenne and J. V. Tien Khang and J.-P. Poivey and F. Lantier and J.-L. Laplanche},
  journal={Archives of Virology},
  year={1999},
  volume={144},
  pages={431-445}
}
  • J.-M. Elsen, Y. Amigues, +7 authors J.-L. Laplanche
  • Published in Archives of Virology 1999
  • DOI:10.1007/s007050050516
SummaryInformation from a scrapie epidemic in a closed INRA Romanov flock is presented. Performances, pedigree, histopathological diagnoses and PrP genotypes were recorded from the beginning of the outbreak (in 1993). Between 1st of April, 1993 and 1st of May, 1997, 1015 animals were exposed to scrapie, and 304 died from this disease. A major influence of the polymorphisms at codons 136, 154 and 171 is shown, A136H154Q171 allele carriers proving to be nearly as resistant as A136R154R171… CONTINUE READING
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