Genetic suppression of ghrelin receptors activates brown adipocyte function and decreases fat storage in rats.

@article{ManoOtagiri2010GeneticSO,
  title={Genetic suppression of ghrelin receptors activates brown adipocyte function and decreases fat storage in rats.},
  author={Asuka Mano-Otagiri and Azusa Iwasaki-Sekino and Takahiro Nemoto and Hisayuki Ohata and Yujin Shuto and Hajime Nakabayashi and Hitoshi Sugihara and Shinichi Oikawa and Tamotsu Shibasaki},
  journal={Regulatory peptides},
  year={2010},
  volume={160 1-3},
  pages={81-90}
}
To clarify the role of ghrelin and its receptor (GHS-R) in the regulatory mechanism of energy metabolism, we analyzed transgenic (Tg) rats expressing an antisense GHS-R mRNA under the control of the tyrosine hydroxylase (TH) promoter. Tg rats showed lower visceral fat weight and higher O(2) consumption, CO(2) production, rectal temperature, dark-period locomotor activity, brown adipose tissue (BAT) weight and uncoupling protein 1 expression compared with wild-type (WT) rats on a standard diet… CONTINUE READING

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The ghrelin/GOAT/GHS-R system and energy metabolism

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