Genetic support for the role of the NLRP3 inflammasome in psoriasis susceptibility.

@article{Carlstrm2012GeneticSF,
  title={Genetic support for the role of the NLRP3 inflammasome in psoriasis susceptibility.},
  author={Maria Carlstr{\"o}m and Anna-Karin Ekman and Stina Petersson and Peter S{\"o}derkvist and C Enerb{\"a}ck},
  journal={Experimental dermatology},
  year={2012},
  volume={21 12},
  pages={
          932-7
        }
}
  • Maria Carlström, Anna-Karin Ekman, +2 authors C Enerbäck
  • Published in Experimental dermatology 2012
  • Biology, Medicine
  • NACHT leucine-rich repeat- and PYD-containing (NLRP)3 protein controls the inflammasome by regulating caspase-1 activity and interleukin (IL)-1β processing. The contribution of IL-1β in the pathogenesis of psoriasis is well recognized. Polymorphisms in NLRP3 and caspase recruitment domain-containing protein (CARD)8, a negative regulator of caspase-1 activity, have been associated with susceptibility to common inflammatory diseases, such as Crohn's disease and rheumatoid arthritis. To… CONTINUE READING

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    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 70 REFERENCES

    Cytosolic DNA triggers inflammasome activation in keratinocytes in psoriatic lesions.

    VIEW 5 EXCERPTS
    HIGHLY INFLUENTIAL