Genetic study of congenital hypothyroidism

  title={Genetic study of congenital hypothyroidism},
  author={Yang Jing-ya},
Congenital hypothyroidism(CH) is the most common neonatal metabolic disorder and can result in severe neurodevelopmental impairment and infertility if untreated.CH is usually sporadic,caused by thyroid dysgenesis and dyshormonogenesis and 2 percent is familial.The genes associated with thyroid gland dysgenesis include TSH receptor and thyroid transcription factors(TTF-1,TTF-2,Pax-8),shh(sonic hedgehog)gene defects.And the genes associated with dyshormonogenesis include the thyroid peroxidase… CONTINUE READING

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