Genetic studies with herpes simplex virus type 1. The isolation of temperature-sensitive mutants, their arrangement into complementation groups and recombination analysis leading to a linkage map.

@article{Brown1973GeneticSW,
  title={Genetic studies with herpes simplex virus type 1. The isolation of temperature-sensitive mutants, their arrangement into complementation groups and recombination analysis leading to a linkage map.},
  author={S M Brown and D A Ritchie and John H. Subak-Sharpe},
  journal={The Journal of general virology},
  year={1973},
  volume={18 3},
  pages={329-46}
}
Nine 5-bromodeoxyuridine-induced temperature-sensitive (ts) mutants were isolated from stocks of a syncytial plaque type mutant (syn) itself derived from the non-syncytial wild-type (syn +) of the GLASGOW strain i7 of herpes simplex virus type i. The nine ts mutants have been assigned to eight cistrons on the basis of different complementation tests. Non-syncytial revertants isolated from the original ts syn mutants were used in reciprocal three-factor crosses of the type: t sX syn x ts Y syn… CONTINUE READING

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