Genetic studies of quantitative MCI and AD phenotypes in ADNI: Progress, opportunities, and plans

@article{Saykin2015GeneticSO,
  title={Genetic studies of quantitative MCI and AD phenotypes in ADNI: Progress, opportunities, and plans},
  author={Andrew J. Saykin and Li Shen and Xiaohui Yao and Sungeun Kim and Kwangsik Nho and Shannon L. Risacher and Vijay K. Ramanan and Tatiana Foroud and Kelley M. Faber and Nadeem Sarwar and Leanne M. Munsie and Xiaolan Hu and Holly D. Soares and Steven G. Potkin and Paul M. Thompson and John S. K. Kauwe and Rima Kaddurah-Daouk and Robert C Green and Arthur W. Toga and Michael W Weiner},
  journal={Alzheimer's & Dementia},
  year={2015},
  volume={11},
  pages={792-814}
}
INTRODUCTION Genetic data from the Alzheimer's Disease Neuroimaging Initiative (ADNI) have been crucial in advancing the understanding of Alzheimer's disease (AD) pathophysiology. Here, we provide an update on sample collection, scientific progress and opportunities, conceptual issues, and future plans. METHODS Lymphoblastoid cell lines and DNA and RNA samples from blood have been collected and banked, and data and biosamples have been widely disseminated. To date, APOE genotyping, genome… CONTINUE READING