Genetic studies of A2M and BACE1 genes in Chinese Han Alzheimer's disease patients.

@article{Cai2005GeneticSO,
  title={Genetic studies of A2M and BACE1 genes in Chinese Han Alzheimer's disease patients.},
  author={Lei Cai and Guomei Tang and Lishan Chen and Bosheng Zhang and San-duo Jiang and Daming Ren},
  journal={Neuroreport},
  year={2005},
  volume={16 9},
  pages={1023-6}
}
We investigated insertion (Ins)/deletion(Del) polymorphism in alpha-2-macroglobulin (A2M), G/C variant in the beta-site amyloid precursor protein-cleaving enzyme 1 (BACE1) and apolipoprotein E (APOE) gene epsilon2/epsilon3/epsilon4 polymorphism in 387 Chinese Han ethnic patients with Alzheimer's disease and healthy study participants. After stratification for APOEepsilon4 status, only the BACE1-G allele with APOEepsilon4 was significantly associated with Alzheimer's disease. Through meta… CONTINUE READING

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