Genetic studies in narcolepsy, a disorder affecting REM sleep.

  title={Genetic studies in narcolepsy, a disorder affecting REM sleep.},
  author={Juliette H Faraco and Xiukun Lin and Renhua Li and Lyn Hinton and Lifeng Lin and Emmanuel Mignot},
  journal={The Journal of heredity},
  volume={90 1},
Narcolepsy is a disabling sleep disorder characterized by excessive daytime sleepiness and abnormal manifestations of rapid eye movement (REM) sleep including cataplexy, sleep paralysis, and hypnagogic hallucinations. It is known to be a complex disorder, with both genetic predisposition and environmental factors playing a role. In humans, susceptibility to narcolepsy is tightly associated with a specific HLA allele, DQB1*0602. In humans and canines, most cases are sporadic. In Doberman… CONTINUE READING