Genetic structures associated with spread of the type Ia trimethoprim-resistant dihydrofolate reductase gene amongst Escherichia coli strains isolated in the Nottingham area of the United Kingdom.

@article{Towner1994GeneticSA,
  title={Genetic structures associated with spread of the type Ia trimethoprim-resistant dihydrofolate reductase gene amongst Escherichia coli strains isolated in the Nottingham area of the United Kingdom.},
  author={Kevin J. Towner and Amanda Brennan and Youzhi Zhang and Carol Holtham and Joanne Brough and Geoffrey I Carter},
  journal={The Journal of antimicrobial chemotherapy},
  year={1994},
  volume={33 1},
  pages={25-32}
}
DNA probes for specific integrase genes were used to study 122 R plasmids encoding the predominant trimethoprim-insusceptible type Ia dihydrofolate reductase (DHFR) found in clinical isolates of Escherichia coli. The predominance of the type Ia DHFR was thought to result from the location of its gene on transposon Tn7, but of trimethoprim R plasmids carrying this gene that were collected between 1978 and 1983, between 1987 and 1988, and during 1992, only 49/60 (81.6%), 30/43 (69.8%) and 9/19… CONTINUE READING
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