Genetic structure and contrasting selection pattern at two major histocompatibility complex genes in wild house mouse populations

@article{kov2011GeneticSA,
  title={Genetic structure and contrasting selection pattern at two major histocompatibility complex genes in wild house mouse populations},
  author={Dagmar {\vC}{\'i}{\vz}kov{\'a} and J{\"o}elle Gouy de Bellocq and Stuart J E Baird and Jaroslav Pi{\'a}lek and Josef Bryja},
  journal={Heredity},
  year={2011},
  volume={106},
  pages={727-740}
}
The mammalian major histocompatibility complex (MHC) is a tightly linked cluster of immune genes, and is often thought of as inherited as a unit. This has led to the hope that studying a single MHC gene will reveal patterns of evolution representative of the MHC as a whole. In this study we analyse a 1000-km transect of MHC variation traversing the European house mouse hybrid zone to compare signals of selection and patterns of diversification at two closely linked MHC class II genes, H-2Aa and… CONTINUE READING
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