Genetic stability of Ross River virus during epidemic spread in nonimmune humans.

@article{Burness1988GeneticSO,
  title={Genetic stability of Ross River virus during epidemic spread in nonimmune humans.},
  author={A. T. Burness and I. Pardoe and S. G. Faragher and S. Vrati and L. Dalgarno},
  journal={Virology},
  year={1988},
  volume={167 2},
  pages={
          639-43
        }
}
We have examined the rate of evolution of Ross River virus, a mosquito-borne RNA virus, during epidemic spread through tens of thousands of nonimmune humans over a period of 10 months. Two regions of the Ross River virus genome were sequenced: the E2 gene (1.2 kb in length), which encodes the major neutralization determinant of the virus, and 0.4 kb of the 3'-untranslated region. In the E2 gene, a single nucleotide change was selected which led to a predicted amino acid change at residue 219… Expand
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