Genetic skin diseases related to desmosomes and corneodesmosomes.

  title={Genetic skin diseases related to desmosomes and corneodesmosomes.},
  author={Akemi Ishida-Yamamoto and Satomi Igawa},
  journal={Journal of dermatological science},
  volume={74 2},
The integrity of the epidermis depends on the cohesion between keratinocytes, and desmosomes are the main adhesion structures. When cells become cornified, desmosomes are modified and transformed into corneodesmosomes. Mutations in the genes encoding desmosomal components underlie several skin diseases including palmoplantar keratoderma and forms of epidermolysis bullosa, indicating the importance of desmosomes as mechanical stress-bearing structures. Other types of genetic defects in a… CONTINUE READING
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