Genetic similarities between latent autoimmune diabetes in adults, type 1 diabetes, and type 2 diabetes.

@article{Cervin2008GeneticSB,
  title={Genetic similarities between latent autoimmune diabetes in adults, type 1 diabetes, and type 2 diabetes.},
  author={Camilla Cervin and Valeriya Lyssenko and Ekaterine Bakhtadze and Eero Lindholm and Peter Nilsson and Tiinamaija Tuomi and Corrado Maria Cilio and Leif Groop},
  journal={Diabetes},
  year={2008},
  volume={57 5},
  pages={1433-7}
}
OBJECTIVE Latent autoimmune diabetes in adults (LADA) is often considered a slowly progressing subtype of type 1 diabetes, although the clinical picture more resembles type 2 diabetes. One way to improve classification is to study whether LADA shares genetic features with type 1 and/or type 2 diabetes. RESEARCH DESIGN AND METHODS To accomplish this, we studied whether LADA shares variation in the HLA locus or INS VNTR and PTPN22 genes with type 1 diabetes or the TCF7L2 gene with type 2… CONTINUE READING
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To accomplish this , we studied whether LADA shares variation in the HLA locus or INS VNTR and PTPN22 genes with type 1 diabetes or the TCF7L2 gene with type 2 diabetes in 361 LADA , 718 type 1 diabetic , and 1,676 type 2 diabetic patients , as well as 1,704 healthy control subjects from Sweden and Finland .
LADA subjects showed , compared with type 2 diabetic patients , increased frequency of risk for the HLA - DQB1 * 0201/*0302 genotype ( 27 vs. 6.9% ; P < 1 x 10(-6 ) ) , with similar frequency as with type 1 diabetes ( 36% ) .
. Latent autoimmune diabetes in adults ( LADA ) is often considered a slowly progressing subtype of type 1 diabetes , although the clinical picture more resembles type 2 diabetes .
To accomplish this , we studied whether LADA shares variation in the HLA locus or INS VNTR and PTPN22 genes with type 1 diabetes or the TCF7L2 gene with type 2 diabetes in 361 LADA , 718 type 1 diabetic , and 1,676 type 2 diabetic patients , as well as 1,704 healthy control subjects from Sweden and Finland .
To accomplish this , we studied whether LADA shares variation in the HLA locus or INS VNTR and PTPN22 genes with type 1 diabetes or the TCF7L2 gene with type 2 diabetes in 361 LADA , 718 type 1 diabetic , and 1,676 type 2 diabetic patients , as well as 1,704 healthy control subjects from Sweden and Finland .
Genetic similarities between latent autoimmune diabetes in adults , type 1 diabetes , and type 2 diabetes . OBJECTIVE
To accomplish this , we studied whether LADA shares variation in the HLA locus or INS VNTR and PTPN22 genes with type 1 diabetes or the TCF7L2 gene with type 2 diabetes in 361 LADA , 718 type 1 diabetic , and 1,676 type 2 diabetic patients , as well as 1,704 healthy control subjects from Sweden and Finland .
LADA subjects showed , compared with type 2 diabetic patients , increased frequency of risk for the HLA - DQB1 * 0201/*0302 genotype ( 27 vs. 6.9% ; P < 1 x 10(-6 ) ) , with similar frequency as with type 1 diabetes ( 36% ) .
. Latent autoimmune diabetes in adults ( LADA ) is often considered a slowly progressing subtype of type 1 diabetes , although the clinical picture more resembles type 2 diabetes .
To accomplish this , we studied whether LADA shares variation in the HLA locus or INS VNTR and PTPN22 genes with type 1 diabetes or the TCF7L2 gene with type 2 diabetes in 361 LADA , 718 type 1 diabetic , and 1,676 type 2 diabetic patients , as well as 1,704 healthy control subjects from Sweden and Finland .
To accomplish this , we studied whether LADA shares variation in the HLA locus or INS VNTR and PTPN22 genes with type 1 diabetes or the TCF7L2 gene with type 2 diabetes in 361 LADA , 718 type 1 diabetic , and 1,676 type 2 diabetic patients , as well as 1,704 healthy control subjects from Sweden and Finland .
Genetic similarities between latent autoimmune diabetes in adults , type 1 diabetes , and type 2 diabetes . OBJECTIVE
To accomplish this , we studied whether LADA shares variation in the HLA locus or INS VNTR and PTPN22 genes with type 1 diabetes or the TCF7L2 gene with type 2 diabetes in 361 LADA , 718 type 1 diabetic , and 1,676 type 2 diabetic patients , as well as 1,704 healthy control subjects from Sweden and Finland .
LADA subjects showed , compared with type 2 diabetic patients , increased frequency of risk for the HLA - DQB1 * 0201/*0302 genotype ( 27 vs. 6.9% ; P < 1 x 10(-6 ) ) , with similar frequency as with type 1 diabetes ( 36% ) .
. Latent autoimmune diabetes in adults ( LADA ) is often considered a slowly progressing subtype of type 1 diabetes , although the clinical picture more resembles type 2 diabetes .
To accomplish this , we studied whether LADA shares variation in the HLA locus or INS VNTR and PTPN22 genes with type 1 diabetes or the TCF7L2 gene with type 2 diabetes in 361 LADA , 718 type 1 diabetic , and 1,676 type 2 diabetic patients , as well as 1,704 healthy control subjects from Sweden and Finland .
To accomplish this , we studied whether LADA shares variation in the HLA locus or INS VNTR and PTPN22 genes with type 1 diabetes or the TCF7L2 gene with type 2 diabetes in 361 LADA , 718 type 1 diabetic , and 1,676 type 2 diabetic patients , as well as 1,704 healthy control subjects from Sweden and Finland .
Genetic similarities between latent autoimmune diabetes in adults , type 1 diabetes , and type 2 diabetes . OBJECTIVE
To accomplish this , we studied whether LADA shares variation in the HLA locus or INS VNTR and PTPN22 genes with type 1 diabetes or the TCF7L2 gene with type 2 diabetes in 361 LADA , 718 type 1 diabetic , and 1,676 type 2 diabetic patients , as well as 1,704 healthy control subjects from Sweden and Finland .
LADA subjects showed , compared with type 2 diabetic patients , increased frequency of risk for the HLA - DQB1 * 0201/*0302 genotype ( 27 vs. 6.9% ; P < 1 x 10(-6 ) ) , with similar frequency as with type 1 diabetes ( 36% ) .
. Latent autoimmune diabetes in adults ( LADA ) is often considered a slowly progressing subtype of type 1 diabetes , although the clinical picture more resembles type 2 diabetes .
To accomplish this , we studied whether LADA shares variation in the HLA locus or INS VNTR and PTPN22 genes with type 1 diabetes or the TCF7L2 gene with type 2 diabetes in 361 LADA , 718 type 1 diabetic , and 1,676 type 2 diabetic patients , as well as 1,704 healthy control subjects from Sweden and Finland .
To accomplish this , we studied whether LADA shares variation in the HLA locus or INS VNTR and PTPN22 genes with type 1 diabetes or the TCF7L2 gene with type 2 diabetes in 361 LADA , 718 type 1 diabetic , and 1,676 type 2 diabetic patients , as well as 1,704 healthy control subjects from Sweden and Finland .
Genetic similarities between latent autoimmune diabetes in adults , type 1 diabetes , and type 2 diabetes . OBJECTIVE
LADA subjects showed , compared with type 2 diabetic patients , increased frequency of risk for the HLA - DQB1 * 0201/*0302 genotype ( 27 vs. 6.9% ; P < 1 x 10(-6 ) ) , with similar frequency as with type 1 diabetes ( 36% ) .
. Latent autoimmune diabetes in adults ( LADA ) is often considered a slowly progressing subtype of type 1 diabetes , although the clinical picture more resembles type 2 diabetes .
To accomplish this , we studied whether LADA shares variation in the HLA locus or INS VNTR and PTPN22 genes with type 1 diabetes or the TCF7L2 gene with type 2 diabetes in 361 LADA , 718 type 1 diabetic , and 1,676 type 2 diabetic patients , as well as 1,704 healthy control subjects from Sweden and Finland .
To accomplish this , we studied whether LADA shares variation in the HLA locus or INS VNTR and PTPN22 genes with type 1 diabetes or the TCF7L2 gene with type 2 diabetes in 361 LADA , 718 type 1 diabetic , and 1,676 type 2 diabetic patients , as well as 1,704 healthy control subjects from Sweden and Finland .
To accomplish this , we studied whether LADA shares variation in the HLA locus or INS VNTR and PTPN22 genes with type 1 diabetes or the TCF7L2 gene with type 2 diabetes in 361 LADA , 718 type 1 diabetic , and 1,676 type 2 diabetic patients , as well as 1,704 healthy control subjects from Sweden and Finland .
Genetic similarities between latent autoimmune diabetes in adults , type 1 diabetes , and type 2 diabetes . OBJECTIVE
To accomplish this , we studied whether LADA shares variation in the HLA locus or INS VNTR and PTPN22 genes with type 1 diabetes or the TCF7L2 gene with type 2 diabetes in 361 LADA , 718 type 1 diabetic , and 1,676 type 2 diabetic patients , as well as 1,704 healthy control subjects from Sweden and Finland .
LADA subjects showed , compared with type 2 diabetic patients , increased frequency of risk for the HLA - DQB1 * 0201/*0302 genotype ( 27 vs. 6.9% ; P < 1 x 10(-6 ) ) , with similar frequency as with type 1 diabetes ( 36% ) .
. Latent autoimmune diabetes in adults ( LADA ) is often considered a slowly progressing subtype of type 1 diabetes , although the clinical picture more resembles type 2 diabetes .
To accomplish this , we studied whether LADA shares variation in the HLA locus or INS VNTR and PTPN22 genes with type 1 diabetes or the TCF7L2 gene with type 2 diabetes in 361 LADA , 718 type 1 diabetic , and 1,676 type 2 diabetic patients , as well as 1,704 healthy control subjects from Sweden and Finland .
To accomplish this , we studied whether LADA shares variation in the HLA locus or INS VNTR and PTPN22 genes with type 1 diabetes or the TCF7L2 gene with type 2 diabetes in 361 LADA , 718 type 1 diabetic , and 1,676 type 2 diabetic patients , as well as 1,704 healthy control subjects from Sweden and Finland .
Genetic similarities between latent autoimmune diabetes in adults , type 1 diabetes , and type 2 diabetes . OBJECTIVE
LADA subjects showed , compared with type 2 diabetic patients , increased frequency of risk for the HLA - DQB1 * 0201/*0302 genotype ( 27 vs. 6.9% ; P < 1 x 10(-6 ) ) , with similar frequency as with type 1 diabetes ( 36% ) .
. Latent autoimmune diabetes in adults ( LADA ) is often considered a slowly progressing subtype of type 1 diabetes , although the clinical picture more resembles type 2 diabetes .
To accomplish this , we studied whether LADA shares variation in the HLA locus or INS VNTR and PTPN22 genes with type 1 diabetes or the TCF7L2 gene with type 2 diabetes in 361 LADA , 718 type 1 diabetic , and 1,676 type 2 diabetic patients , as well as 1,704 healthy control subjects from Sweden and Finland .
To accomplish this , we studied whether LADA shares variation in the HLA locus or INS VNTR and PTPN22 genes with type 1 diabetes or the TCF7L2 gene with type 2 diabetes in 361 LADA , 718 type 1 diabetic , and 1,676 type 2 diabetic patients , as well as 1,704 healthy control subjects from Sweden and Finland .
To accomplish this , we studied whether LADA shares variation in the HLA locus or INS VNTR and PTPN22 genes with type 1 diabetes or the TCF7L2 gene with type 2 diabetes in 361 LADA , 718 type 1 diabetic , and 1,676 type 2 diabetic patients , as well as 1,704 healthy control subjects from Sweden and Finland .
Genetic similarities between latent autoimmune diabetes in adults , type 1 diabetes , and type 2 diabetes . OBJECTIVE
To accomplish this , we studied whether LADA shares variation in the HLA locus or INS VNTR and PTPN22 genes with type 1 diabetes or the TCF7L2 gene with type 2 diabetes in 361 LADA , 718 type 1 diabetic , and 1,676 type 2 diabetic patients , as well as 1,704 healthy control subjects from Sweden and Finland .
Notably , the frequency of the type 2 diabetes - associated CT / TT genotypes of rs7903146 in the TCF7L2 were increased in LADA subjects ( 52.8% ; P = 0.03 ) , to the same extent as in type 2 diabetic subjects ( 54.1% , P = 3 x 10(-7 ) ) , compared with control subjects ( 44.8% ) and type 1 diabetic subjects ( 43.3% ) .
Genetic similarities between latent autoimmune diabetes in adults , type 1 diabetes , and type 2 diabetes . OBJECTIVE
To accomplish this , we studied whether LADA shares variation in the HLA locus or INS VNTR and PTPN22 genes with type 1 diabetes or the TCF7L2 gene with type 2 diabetes in 361 LADA , 718 type 1 diabetic , and 1,676 type 2 diabetic patients , as well as 1,704 healthy control subjects from Sweden and Finland .
To accomplish this , we studied whether LADA shares variation in the HLA locus or INS VNTR and PTPN22 genes with type 1 diabetes or the TCF7L2 gene with type 2 diabetes in 361 LADA , 718 type 1 diabetic , and 1,676 type 2 diabetic patients , as well as 1,704 healthy control subjects from Sweden and Finland .
Notably , the frequency of the type 2 diabetes - associated CT / TT genotypes of rs7903146 in the TCF7L2 were increased in LADA subjects ( 52.8% ; P = 0.03 ) , to the same extent as in type 2 diabetic subjects ( 54.1% , P = 3 x 10(-7 ) ) , compared with control subjects ( 44.8% ) and type 1 diabetic subjects ( 43.3% ) .
. Latent autoimmune diabetes in adults ( LADA ) is often considered a slowly progressing subtype of type 1 diabetes , although the clinical picture more resembles type 2 diabetes .
To accomplish this , we studied whether LADA shares variation in the HLA locus or INS VNTR and PTPN22 genes with type 1 diabetes or the TCF7L2 gene with type 2 diabetes in 361 LADA , 718 type 1 diabetic , and 1,676 type 2 diabetic patients , as well as 1,704 healthy control subjects from Sweden and Finland .
Notably , the frequency of the type 2 diabetes - associated CT / TT genotypes of rs7903146 in the TCF7L2 were increased in LADA subjects ( 52.8% ; P = 0.03 ) , to the same extent as in type 2 diabetic subjects ( 54.1% , P = 3 x 10(-7 ) ) , compared with control subjects ( 44.8% ) and type 1 diabetic subjects ( 43.3% ) .
Genetic similarities between latent autoimmune diabetes in adults , type 1 diabetes , and type 2 diabetes . OBJECTIVE
To accomplish this , we studied whether LADA shares variation in the HLA locus or INS VNTR and PTPN22 genes with type 1 diabetes or the TCF7L2 gene with type 2 diabetes in 361 LADA , 718 type 1 diabetic , and 1,676 type 2 diabetic patients , as well as 1,704 healthy control subjects from Sweden and Finland .
To accomplish this , we studied whether LADA shares variation in the HLA locus or INS VNTR and PTPN22 genes with type 1 diabetes or the TCF7L2 gene with type 2 diabetes in 361 LADA , 718 type 1 diabetic , and 1,676 type 2 diabetic patients , as well as 1,704 healthy control subjects from Sweden and Finland .
Notably , the frequency of the type 2 diabetes - associated CT / TT genotypes of rs7903146 in the TCF7L2 were increased in LADA subjects ( 52.8% ; P = 0.03 ) , to the same extent as in type 2 diabetic subjects ( 54.1% , P = 3 x 10(-7 ) ) , compared with control subjects ( 44.8% ) and type 1 diabetic subjects ( 43.3% ) .
. Latent autoimmune diabetes in adults ( LADA ) is often considered a slowly progressing subtype of type 1 diabetes , although the clinical picture more resembles type 2 diabetes .
To accomplish this , we studied whether LADA shares variation in the HLA locus or INS VNTR and PTPN22 genes with type 1 diabetes or the TCF7L2 gene with type 2 diabetes in 361 LADA , 718 type 1 diabetic , and 1,676 type 2 diabetic patients , as well as 1,704 healthy control subjects from Sweden and Finland .
Notably , the frequency of the type 2 diabetes - associated CT / TT genotypes of rs7903146 in the TCF7L2 were increased in LADA subjects ( 52.8% ; P = 0.03 ) , to the same extent as in type 2 diabetic subjects ( 54.1% , P = 3 x 10(-7 ) ) , compared with control subjects ( 44.8% ) and type 1 diabetic subjects ( 43.3% ) .
Genetic similarities between latent autoimmune diabetes in adults , type 1 diabetes , and type 2 diabetes . OBJECTIVE
To accomplish this , we studied whether LADA shares variation in the HLA locus or INS VNTR and PTPN22 genes with type 1 diabetes or the TCF7L2 gene with type 2 diabetes in 361 LADA , 718 type 1 diabetic , and 1,676 type 2 diabetic patients , as well as 1,704 healthy control subjects from Sweden and Finland .
To accomplish this , we studied whether LADA shares variation in the HLA locus or INS VNTR and PTPN22 genes with type 1 diabetes or the TCF7L2 gene with type 2 diabetes in 361 LADA , 718 type 1 diabetic , and 1,676 type 2 diabetic patients , as well as 1,704 healthy control subjects from Sweden and Finland .
Notably , the frequency of the type 2 diabetes - associated CT / TT genotypes of rs7903146 in the TCF7L2 were increased in LADA subjects ( 52.8% ; P = 0.03 ) , to the same extent as in type 2 diabetic subjects ( 54.1% , P = 3 x 10(-7 ) ) , compared with control subjects ( 44.8% ) and type 1 diabetic subjects ( 43.3% ) .
. Latent autoimmune diabetes in adults ( LADA ) is often considered a slowly progressing subtype of type 1 diabetes , although the clinical picture more resembles type 2 diabetes .
To accomplish this , we studied whether LADA shares variation in the HLA locus or INS VNTR and PTPN22 genes with type 1 diabetes or the TCF7L2 gene with type 2 diabetes in 361 LADA , 718 type 1 diabetic , and 1,676 type 2 diabetic patients , as well as 1,704 healthy control subjects from Sweden and Finland .
Notably , the frequency of the type 2 diabetes - associated CT / TT genotypes of rs7903146 in the TCF7L2 were increased in LADA subjects ( 52.8% ; P = 0.03 ) , to the same extent as in type 2 diabetic subjects ( 54.1% , P = 3 x 10(-7 ) ) , compared with control subjects ( 44.8% ) and type 1 diabetic subjects ( 43.3% ) .
Genetic similarities between latent autoimmune diabetes in adults , type 1 diabetes , and type 2 diabetes . OBJECTIVE
To accomplish this , we studied whether LADA shares variation in the HLA locus or INS VNTR and PTPN22 genes with type 1 diabetes or the TCF7L2 gene with type 2 diabetes in 361 LADA , 718 type 1 diabetic , and 1,676 type 2 diabetic patients , as well as 1,704 healthy control subjects from Sweden and Finland .
To accomplish this , we studied whether LADA shares variation in the HLA locus or INS VNTR and PTPN22 genes with type 1 diabetes or the TCF7L2 gene with type 2 diabetes in 361 LADA , 718 type 1 diabetic , and 1,676 type 2 diabetic patients , as well as 1,704 healthy control subjects from Sweden and Finland .
Notably , the frequency of the type 2 diabetes - associated CT / TT genotypes of rs7903146 in the TCF7L2 were increased in LADA subjects ( 52.8% ; P = 0.03 ) , to the same extent as in type 2 diabetic subjects ( 54.1% , P = 3 x 10(-7 ) ) , compared with control subjects ( 44.8% ) and type 1 diabetic subjects ( 43.3% ) .
. Latent autoimmune diabetes in adults ( LADA ) is often considered a slowly progressing subtype of type 1 diabetes , although the clinical picture more resembles type 2 diabetes .
. Latent autoimmune diabetes in adults ( LADA ) is often considered a slowly progressing subtype of type 1 diabetes , although the clinical picture more resembles type 2 diabetes .
To accomplish this , we studied whether LADA shares variation in the HLA locus or INS VNTR and PTPN22 genes with type 1 diabetes or the TCF7L2 gene with type 2 diabetes in 361 LADA , 718 type 1 diabetic , and 1,676 type 2 diabetic patients , as well as 1,704 healthy control subjects from Sweden and Finland .
To accomplish this , we studied whether LADA shares variation in the HLA locus or INS VNTR and PTPN22 genes with type 1 diabetes or the TCF7L2 gene with type 2 diabetes in 361 LADA , 718 type 1 diabetic , and 1,676 type 2 diabetic patients , as well as 1,704 healthy control subjects from Sweden and Finland .
To accomplish this , we studied whether LADA shares variation in the HLA locus or INS VNTR and PTPN22 genes with type 1 diabetes or the TCF7L2 gene with type 2 diabetes in 361 LADA , 718 type 1 diabetic , and 1,676 type 2 diabetic patients , as well as 1,704 healthy control subjects from Sweden and Finland .
Genetic similarities between latent autoimmune diabetes in adults , type 1 diabetes , and type 2 diabetes . OBJECTIVE
Notably , the frequency of the type 2 diabetes - associated CT / TT genotypes of rs7903146 in the TCF7L2 were increased in LADA subjects ( 52.8% ; P = 0.03 ) , to the same extent as in type 2 diabetic subjects ( 54.1% , P = 3 x 10(-7 ) ) , compared with control subjects ( 44.8% ) and type 1 diabetic subjects ( 43.3% ) .
Notably , the frequency of the type 2 diabetes - associated CT / TT genotypes of rs7903146 in the TCF7L2 were increased in LADA subjects ( 52.8% ; P = 0.03 ) , to the same extent as in type 2 diabetic subjects ( 54.1% , P = 3 x 10(-7 ) ) , compared with control subjects ( 44.8% ) and type 1 diabetic subjects ( 43.3% ) .
To accomplish this , we studied whether LADA shares variation in the HLA locus or INS VNTR and PTPN22 genes with type 1 diabetes or the TCF7L2 gene with type 2 diabetes in 361 LADA , 718 type 1 diabetic , and 1,676 type 2 diabetic patients , as well as 1,704 healthy control subjects from Sweden and Finland .
Notably , the frequency of the type 2 diabetes - associated CT / TT genotypes of rs7903146 in the TCF7L2 were increased in LADA subjects ( 52.8% ; P = 0.03 ) , to the same extent as in type 2 diabetic subjects ( 54.1% , P = 3 x 10(-7 ) ) , compared with control subjects ( 44.8% ) and type 1 diabetic subjects ( 43.3% ) .
Genetic similarities between latent autoimmune diabetes in adults , type 1 diabetes , and type 2 diabetes . OBJECTIVE
To accomplish this , we studied whether LADA shares variation in the HLA locus or INS VNTR and PTPN22 genes with type 1 diabetes or the TCF7L2 gene with type 2 diabetes in 361 LADA , 718 type 1 diabetic , and 1,676 type 2 diabetic patients , as well as 1,704 healthy control subjects from Sweden and Finland .
To accomplish this , we studied whether LADA shares variation in the HLA locus or INS VNTR and PTPN22 genes with type 1 diabetes or the TCF7L2 gene with type 2 diabetes in 361 LADA , 718 type 1 diabetic , and 1,676 type 2 diabetic patients , as well as 1,704 healthy control subjects from Sweden and Finland .
Notably , the frequency of the type 2 diabetes - associated CT / TT genotypes of rs7903146 in the TCF7L2 were increased in LADA subjects ( 52.8% ; P = 0.03 ) , to the same extent as in type 2 diabetic subjects ( 54.1% , P = 3 x 10(-7 ) ) , compared with control subjects ( 44.8% ) and type 1 diabetic subjects ( 43.3% ) .
. Latent autoimmune diabetes in adults ( LADA ) is often considered a slowly progressing subtype of type 1 diabetes , although the clinical picture more resembles type 2 diabetes .
. Latent autoimmune diabetes in adults ( LADA ) is often considered a slowly progressing subtype of type 1 diabetes , although the clinical picture more resembles type 2 diabetes .
To accomplish this , we studied whether LADA shares variation in the HLA locus or INS VNTR and PTPN22 genes with type 1 diabetes or the TCF7L2 gene with type 2 diabetes in 361 LADA , 718 type 1 diabetic , and 1,676 type 2 diabetic patients , as well as 1,704 healthy control subjects from Sweden and Finland .
To accomplish this , we studied whether LADA shares variation in the HLA locus or INS VNTR and PTPN22 genes with type 1 diabetes or the TCF7L2 gene with type 2 diabetes in 361 LADA , 718 type 1 diabetic , and 1,676 type 2 diabetic patients , as well as 1,704 healthy control subjects from Sweden and Finland .
To accomplish this , we studied whether LADA shares variation in the HLA locus or INS VNTR and PTPN22 genes with type 1 diabetes or the TCF7L2 gene with type 2 diabetes in 361 LADA , 718 type 1 diabetic , and 1,676 type 2 diabetic patients , as well as 1,704 healthy control subjects from Sweden and Finland .
Genetic similarities between latent autoimmune diabetes in adults , type 1 diabetes , and type 2 diabetes . OBJECTIVE
Notably , the frequency of the type 2 diabetes - associated CT / TT genotypes of rs7903146 in the TCF7L2 were increased in LADA subjects ( 52.8% ; P = 0.03 ) , to the same extent as in type 2 diabetic subjects ( 54.1% , P = 3 x 10(-7 ) ) , compared with control subjects ( 44.8% ) and type 1 diabetic subjects ( 43.3% ) .
Notably , the frequency of the type 2 diabetes - associated CT / TT genotypes of rs7903146 in the TCF7L2 were increased in LADA subjects ( 52.8% ; P = 0.03 ) , to the same extent as in type 2 diabetic subjects ( 54.1% , P = 3 x 10(-7 ) ) , compared with control subjects ( 44.8% ) and type 1 diabetic subjects ( 43.3% ) .
Genetic similarities between latent autoimmune diabetes in adults , type 1 diabetes , and type 2 diabetes . OBJECTIVE
. Latent autoimmune diabetes in adults ( LADA ) is often considered a slowly progressing subtype of type 1 diabetes , although the clinical picture more resembles type 2 diabetes .
Genetic similarities between latent autoimmune diabetes in adults , type 1 diabetes , and type 2 diabetes . OBJECTIVE
. Latent autoimmune diabetes in adults ( LADA ) is often considered a slowly progressing subtype of type 1 diabetes , although the clinical picture more resembles type 2 diabetes .
LADA subjects showed , compared with type 2 diabetic patients , increased frequency of risk for the HLA - DQB1 * 0201/*0302 genotype ( 27 vs. 6.9% ; P < 1 x 10(-6 ) ) , with similar frequency as with type 1 diabetes ( 36% ) .
. Latent autoimmune diabetes in adults ( LADA ) is often considered a slowly progressing subtype of type 1 diabetes , although the clinical picture more resembles type 2 diabetes .
To accomplish this , we studied whether LADA shares variation in the HLA locus or INS VNTR and PTPN22 genes with type 1 diabetes or the TCF7L2 gene with type 2 diabetes in 361 LADA , 718 type 1 diabetic , and 1,676 type 2 diabetic patients , as well as 1,704 healthy control subjects from Sweden and Finland .
To accomplish this , we studied whether LADA shares variation in the HLA locus or INS VNTR and PTPN22 genes with type 1 diabetes or the TCF7L2 gene with type 2 diabetes in 361 LADA , 718 type 1 diabetic , and 1,676 type 2 diabetic patients , as well as 1,704 healthy control subjects from Sweden and Finland .
To accomplish this , we studied whether LADA shares variation in the HLA locus or INS VNTR and PTPN22 genes with type 1 diabetes or the TCF7L2 gene with type 2 diabetes in 361 LADA , 718 type 1 diabetic , and 1,676 type 2 diabetic patients , as well as 1,704 healthy control subjects from Sweden and Finland .
Genetic similarities between latent autoimmune diabetes in adults , type 1 diabetes , and type 2 diabetes . OBJECTIVE
LADA subjects showed , compared with type 2 diabetic patients , increased frequency of risk for the HLA - DQB1 * 0201/*0302 genotype ( 27 vs. 6.9% ; P < 1 x 10(-6 ) ) , with similar frequency as with type 1 diabetes ( 36% ) .
. Latent autoimmune diabetes in adults ( LADA ) is often considered a slowly progressing subtype of type 1 diabetes , although the clinical picture more resembles type 2 diabetes .
To accomplish this , we studied whether LADA shares variation in the HLA locus or INS VNTR and PTPN22 genes with type 1 diabetes or the TCF7L2 gene with type 2 diabetes in 361 LADA , 718 type 1 diabetic , and 1,676 type 2 diabetic patients , as well as 1,704 healthy control subjects from Sweden and Finland .
To accomplish this , we studied whether LADA shares variation in the HLA locus or INS VNTR and PTPN22 genes with type 1 diabetes or the TCF7L2 gene with type 2 diabetes in 361 LADA , 718 type 1 diabetic , and 1,676 type 2 diabetic patients , as well as 1,704 healthy control subjects from Sweden and Finland .
To accomplish this , we studied whether LADA shares variation in the HLA locus or INS VNTR and PTPN22 genes with type 1 diabetes or the TCF7L2 gene with type 2 diabetes in 361 LADA , 718 type 1 diabetic , and 1,676 type 2 diabetic patients , as well as 1,704 healthy control subjects from Sweden and Finland .
Genetic similarities between latent autoimmune diabetes in adults , type 1 diabetes , and type 2 diabetes . OBJECTIVE
LADA subjects showed , compared with type 2 diabetic patients , increased frequency of risk for the HLA - DQB1 * 0201/*0302 genotype ( 27 vs. 6.9% ; P < 1 x 10(-6 ) ) , with similar frequency as with type 1 diabetes ( 36% ) .
. Latent autoimmune diabetes in adults ( LADA ) is often considered a slowly progressing subtype of type 1 diabetes , although the clinical picture more resembles type 2 diabetes .
To accomplish this , we studied whether LADA shares variation in the HLA locus or INS VNTR and PTPN22 genes with type 1 diabetes or the TCF7L2 gene with type 2 diabetes in 361 LADA , 718 type 1 diabetic , and 1,676 type 2 diabetic patients , as well as 1,704 healthy control subjects from Sweden and Finland .
To accomplish this , we studied whether LADA shares variation in the HLA locus or INS VNTR and PTPN22 genes with type 1 diabetes or the TCF7L2 gene with type 2 diabetes in 361 LADA , 718 type 1 diabetic , and 1,676 type 2 diabetic patients , as well as 1,704 healthy control subjects from Sweden and Finland .
To accomplish this , we studied whether LADA shares variation in the HLA locus or INS VNTR and PTPN22 genes with type 1 diabetes or the TCF7L2 gene with type 2 diabetes in 361 LADA , 718 type 1 diabetic , and 1,676 type 2 diabetic patients , as well as 1,704 healthy control subjects from Sweden and Finland .
Genetic similarities between latent autoimmune diabetes in adults , type 1 diabetes , and type 2 diabetes . OBJECTIVE
. Latent autoimmune diabetes in adults ( LADA ) is often considered a slowly progressing subtype of type 1 diabetes , although the clinical picture more resembles type 2 diabetes .
To accomplish this , we studied whether LADA shares variation in the HLA locus or INS VNTR and PTPN22 genes with type 1 diabetes or the TCF7L2 gene with type 2 diabetes in 361 LADA , 718 type 1 diabetic , and 1,676 type 2 diabetic patients , as well as 1,704 healthy control subjects from Sweden and Finland .
Genetic similarities between latent autoimmune diabetes in adults , type 1 diabetes , and type 2 diabetes . OBJECTIVE
. Latent autoimmune diabetes in adults ( LADA ) is often considered a slowly progressing subtype of type 1 diabetes , although the clinical picture more resembles type 2 diabetes .
To accomplish this , we studied whether LADA shares variation in the HLA locus or INS VNTR and PTPN22 genes with type 1 diabetes or the TCF7L2 gene with type 2 diabetes in 361 LADA , 718 type 1 diabetic , and 1,676 type 2 diabetic patients , as well as 1,704 healthy control subjects from Sweden and Finland .
Genetic similarities between latent autoimmune diabetes in adults , type 1 diabetes , and type 2 diabetes . OBJECTIVE
. Latent autoimmune diabetes in adults ( LADA ) is often considered a slowly progressing subtype of type 1 diabetes , although the clinical picture more resembles type 2 diabetes .
To accomplish this , we studied whether LADA shares variation in the HLA locus or INS VNTR and PTPN22 genes with type 1 diabetes or the TCF7L2 gene with type 2 diabetes in 361 LADA , 718 type 1 diabetic , and 1,676 type 2 diabetic patients , as well as 1,704 healthy control subjects from Sweden and Finland .
Genetic similarities between latent autoimmune diabetes in adults , type 1 diabetes , and type 2 diabetes . OBJECTIVE
. Latent autoimmune diabetes in adults ( LADA ) is often considered a slowly progressing subtype of type 1 diabetes , although the clinical picture more resembles type 2 diabetes .
Genetic similarities between latent autoimmune diabetes in adults , type 1 diabetes , and type 2 diabetes . OBJECTIVE
Genetic similarities between latent autoimmune diabetes in adults , type 1 diabetes , and type 2 diabetes . OBJECTIVE
. Latent autoimmune diabetes in adults ( LADA ) is often considered a slowly progressing subtype of type 1 diabetes , although the clinical picture more resembles type 2 diabetes .
. Latent autoimmune diabetes in adults ( LADA ) is often considered a slowly progressing subtype of type 1 diabetes , although the clinical picture more resembles type 2 diabetes .
To accomplish this , we studied whether LADA shares variation in the HLA locus or INS VNTR and PTPN22 genes with type 1 diabetes or the TCF7L2 gene with type 2 diabetes in 361 LADA , 718 type 1 diabetic , and 1,676 type 2 diabetic patients , as well as 1,704 healthy control subjects from Sweden and Finland .
To accomplish this , we studied whether LADA shares variation in the HLA locus or INS VNTR and PTPN22 genes with type 1 diabetes or the TCF7L2 gene with type 2 diabetes in 361 LADA , 718 type 1 diabetic , and 1,676 type 2 diabetic patients , as well as 1,704 healthy control subjects from Sweden and Finland .
To accomplish this , we studied whether LADA shares variation in the HLA locus or INS VNTR and PTPN22 genes with type 1 diabetes or the TCF7L2 gene with type 2 diabetes in 361 LADA , 718 type 1 diabetic , and 1,676 type 2 diabetic patients , as well as 1,704 healthy control subjects from Sweden and Finland .
Genetic similarities between latent autoimmune diabetes in adults , type 1 diabetes , and type 2 diabetes . OBJECTIVE
Notably , the frequency of the type 2 diabetes - associated CT / TT genotypes of rs7903146 in the TCF7L2 were increased in LADA subjects ( 52.8% ; P = 0.03 ) , to the same extent as in type 2 diabetic subjects ( 54.1% , P = 3 x 10(-7 ) ) , compared with control subjects ( 44.8% ) and type 1 diabetic subjects ( 43.3% ) .
Notably , the frequency of the type 2 diabetes - associated CT / TT genotypes of rs7903146 in the TCF7L2 were increased in LADA subjects ( 52.8% ; P = 0.03 ) , to the same extent as in type 2 diabetic subjects ( 54.1% , P = 3 x 10(-7 ) ) , compared with control subjects ( 44.8% ) and type 1 diabetic subjects ( 43.3% ) .
. Latent autoimmune diabetes in adults ( LADA ) is often considered a slowly progressing subtype of type 1 diabetes , although the clinical picture more resembles type 2 diabetes .
To accomplish this , we studied whether LADA shares variation in the HLA locus or INS VNTR and PTPN22 genes with type 1 diabetes or the TCF7L2 gene with type 2 diabetes in 361 LADA , 718 type 1 diabetic , and 1,676 type 2 diabetic patients , as well as 1,704 healthy control subjects from Sweden and Finland .
To accomplish this , we studied whether LADA shares variation in the HLA locus or INS VNTR and PTPN22 genes with type 1 diabetes or the TCF7L2 gene with type 2 diabetes in 361 LADA , 718 type 1 diabetic , and 1,676 type 2 diabetic patients , as well as 1,704 healthy control subjects from Sweden and Finland .
To accomplish this , we studied whether LADA shares variation in the HLA locus or INS VNTR and PTPN22 genes with type 1 diabetes or the TCF7L2 gene with type 2 diabetes in 361 LADA , 718 type 1 diabetic , and 1,676 type 2 diabetic patients , as well as 1,704 healthy control subjects from Sweden and Finland .
Genetic similarities between latent autoimmune diabetes in adults , type 1 diabetes , and type 2 diabetes . OBJECTIVE
Notably , the frequency of the type 2 diabetes - associated CT / TT genotypes of rs7903146 in the TCF7L2 were increased in LADA subjects ( 52.8% ; P = 0.03 ) , to the same extent as in type 2 diabetic subjects ( 54.1% , P = 3 x 10(-7 ) ) , compared with control subjects ( 44.8% ) and type 1 diabetic subjects ( 43.3% ) .
Notably , the frequency of the type 2 diabetes - associated CT / TT genotypes of rs7903146 in the TCF7L2 were increased in LADA subjects ( 52.8% ; P = 0.03 ) , to the same extent as in type 2 diabetic subjects ( 54.1% , P = 3 x 10(-7 ) ) , compared with control subjects ( 44.8% ) and type 1 diabetic subjects ( 43.3% ) .
. Latent autoimmune diabetes in adults ( LADA ) is often considered a slowly progressing subtype of type 1 diabetes , although the clinical picture more resembles type 2 diabetes .
To accomplish this , we studied whether LADA shares variation in the HLA locus or INS VNTR and PTPN22 genes with type 1 diabetes or the TCF7L2 gene with type 2 diabetes in 361 LADA , 718 type 1 diabetic , and 1,676 type 2 diabetic patients , as well as 1,704 healthy control subjects from Sweden and Finland .
To accomplish this , we studied whether LADA shares variation in the HLA locus or INS VNTR and PTPN22 genes with type 1 diabetes or the TCF7L2 gene with type 2 diabetes in 361 LADA , 718 type 1 diabetic , and 1,676 type 2 diabetic patients , as well as 1,704 healthy control subjects from Sweden and Finland .
To accomplish this , we studied whether LADA shares variation in the HLA locus or INS VNTR and PTPN22 genes with type 1 diabetes or the TCF7L2 gene with type 2 diabetes in 361 LADA , 718 type 1 diabetic , and 1,676 type 2 diabetic patients , as well as 1,704 healthy control subjects from Sweden and Finland .
Genetic similarities between latent autoimmune diabetes in adults , type 1 diabetes , and type 2 diabetes . OBJECTIVE
Notably , the frequency of the type 2 diabetes - associated CT / TT genotypes of rs7903146 in the TCF7L2 were increased in LADA subjects ( 52.8% ; P = 0.03 ) , to the same extent as in type 2 diabetic subjects ( 54.1% , P = 3 x 10(-7 ) ) , compared with control subjects ( 44.8% ) and type 1 diabetic subjects ( 43.3% ) .
Notably , the frequency of the type 2 diabetes - associated CT / TT genotypes of rs7903146 in the TCF7L2 were increased in LADA subjects ( 52.8% ; P = 0.03 ) , to the same extent as in type 2 diabetic subjects ( 54.1% , P = 3 x 10(-7 ) ) , compared with control subjects ( 44.8% ) and type 1 diabetic subjects ( 43.3% ) .
. Latent autoimmune diabetes in adults ( LADA ) is often considered a slowly progressing subtype of type 1 diabetes , although the clinical picture more resembles type 2 diabetes .
To accomplish this , we studied whether LADA shares variation in the HLA locus or INS VNTR and PTPN22 genes with type 1 diabetes or the TCF7L2 gene with type 2 diabetes in 361 LADA , 718 type 1 diabetic , and 1,676 type 2 diabetic patients , as well as 1,704 healthy control subjects from Sweden and Finland .
Genetic similarities between latent autoimmune diabetes in adults , type 1 diabetes , and type 2 diabetes . OBJECTIVE
. Latent autoimmune diabetes in adults ( LADA ) is often considered a slowly progressing subtype of type 1 diabetes , although the clinical picture more resembles type 2 diabetes .
Genetic similarities between latent autoimmune diabetes in adults , type 1 diabetes , and type 2 diabetes . OBJECTIVE
Genetic similarities between latent autoimmune diabetes in adults , type 1 diabetes , and type 2 diabetes . OBJECTIVE
. Latent autoimmune diabetes in adults ( LADA ) is often considered a slowly progressing subtype of type 1 diabetes , although the clinical picture more resembles type 2 diabetes .
. Latent autoimmune diabetes in adults ( LADA ) is often considered a slowly progressing subtype of type 1 diabetes , although the clinical picture more resembles type 2 diabetes .
. Latent autoimmune diabetes in adults ( LADA ) is often considered a slowly progressing subtype of type 1 diabetes , although the clinical picture more resembles type 2 diabetes .
Genetic similarities between latent autoimmune diabetes in adults , type 1 diabetes , and type 2 diabetes . OBJECTIVE
Genetic similarities between latent autoimmune diabetes in adults , type 1 diabetes , and type 2 diabetes . OBJECTIVE
To accomplish this , we studied whether LADA shares variation in the HLA locus or INS VNTR and PTPN22 genes with type 1 diabetes or the TCF7L2 gene with type 2 diabetes in 361 LADA , 718 type 1 diabetic , and 1,676 type 2 diabetic patients , as well as 1,704 healthy control subjects from Sweden and Finland .
Genetic similarities between latent autoimmune diabetes in adults , type 1 diabetes , and type 2 diabetes . OBJECTIVE
Genetic similarities between latent autoimmune diabetes in adults , type 1 diabetes , and type 2 diabetes . OBJECTIVE
. Latent autoimmune diabetes in adults ( LADA ) is often considered a slowly progressing subtype of type 1 diabetes , although the clinical picture more resembles type 2 diabetes .
. Latent autoimmune diabetes in adults ( LADA ) is often considered a slowly progressing subtype of type 1 diabetes , although the clinical picture more resembles type 2 diabetes .
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