Genetic screening for PRA-associated mutations in multiple dog breeds shows that PRA is heterogeneous within and between breeds.

@article{Downs2014GeneticSF,
  title={Genetic screening for PRA-associated mutations in multiple dog breeds shows that PRA is heterogeneous within and between breeds.},
  author={Louise M. Downs and Rebekkah J. Hitti and Silvia Pregnolato and Cathryn Mellersh},
  journal={Veterinary ophthalmology},
  year={2014},
  volume={17 2},
  pages={126-30}
}
OBJECTIVE To assess the extent of progressive retinal atrophy (PRA) genetic heterogeneity within and between domestic dog breeds. METHODS DNA from 231 dogs with PRA, representing 36 breeds, was screened for 17 mutations previously associated with PRA in at least one breed of dog. Screening methods included amplified fragment size discrimination using gel electrophoresis or detection of fluorescence, (TaqMan(®) ; Life Technologies, Carlsbad, CA, USA) allelic discrimination, and Sanger… CONTINUE READING