Genetic risk of neuropsychological impairment in schizophrenia: a study of monozygotic twins discordant and concordant for the disorder.

@article{Goldberg1995GeneticRO,
  title={Genetic risk of neuropsychological impairment in schizophrenia: a study of monozygotic twins discordant and concordant for the disorder.},
  author={Terry E. Goldberg and E. Fuller Torrey and James M. Gold and Llewelyn B Bigelow and R D Ragland and Eric Taylor and Daniel R. Weinberger},
  journal={Schizophrenia research},
  year={1995},
  volume={17 1},
  pages={77-84}
}
We used a paradigm involving monozygotic (MZ) twin pairs discordant for schizophrenia (n = 20) and concordant for schizophrenia (n = 8), as well as normal MZ twin pairs (n = 7) in order to study cognitive measures of genetic risk in schizophrenia. A comparison between the unaffected twins from the discordant sample and the normal twins indicated subtle attenuations in some aspects of memory and executive functioning in the unaffected group and thus provided evidence for cognitive markers of a… CONTINUE READING