Genetic risk of clozapine-induced leukopenia and neutropenia: a genome-wide association study

@article{Chen2020GeneticRO,
  title={Genetic risk of clozapine-induced leukopenia and neutropenia: a genome-wide association study},
  author={Jianhua Chen and Ping Yang and Qian Zhang and Ruirui Chen and Pengkun Wang and Benxiu Liu and Wensheng Sun and Xuemin Jian and Si-Ying Xiang and Juan Zhou and Ningning Li and Ke Wang and Chengwen Gao and Ya Wen and Chuanhong Wu and Jinmai Zhang and Yalin Zhao and Qiangzhen Yang and Meihang Li and Robert J. Stewart and Yuanchao Sun and Dun Pan and Y Niu and Zhuo Wang and Yifeng Xu and Xing-wang Li and Lin He and Zhiqiang Li and Yongyong Shi},
  journal={Translational Psychiatry},
  year={2020},
  volume={11}
}
Background Clozapine is considered to be the most effective antipsychotic medication for schizophrenia. However, it is associated with several adverse effects such as leukopenia, and the underlying mechanism has not yet been fully elucidated. The authors performed a genome-wide association study (GWAS) in a Chinese population to identify genetic markers for clozapine-induced leukopenia (CIL) and clozapine-induced neutropenia (CIN). Methods A total of 1879 patients (225 CIL cases, including 43… 

Two Patients with Schizophrenia Treated with Clozapine Developed Neutropenia After Receiving a COVID-19 Vaccine

Physicians need to have a strict follow-up protocol in place for patients after vaccination for COVID-19, as two cases of patients with schizophrenia who were treated with clozapine and showed neutropenia after receiving a CO VID-19 vaccine were observed.

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