Genetic risk for earlier menarche also influences peripubertal body mass index.

@article{Johnson2013GeneticRF,
  title={Genetic risk for earlier menarche also influences peripubertal body mass index.},
  author={William F Johnson and Audrey C. Choh and Joanne E. Curran and Stefan A. Czerwinski and Claire Bellis and Thomas D. Dyer and John Blangero and Bradford Towne and Ellen W. Demerath},
  journal={American journal of physical anthropology},
  year={2013},
  volume={150 1},
  pages={10-20}
}
It is unclear whether earlier age at menarche is associated with higher body mass index (BMI) because they share a common genetic underpinning. We investigated the impact of single nucleotide polymorphisms (SNPs) influencing menarche timing on peripubertal BMI. For 556 Fels Longitudinal Study children (277 boys/279 girls) born 1928-1992, a genetic risk score (GRS(42)) was computed as the sum of the number of risk alleles in 42 putative menarche SNPs. Serial BMI Z-scores within ±6.99 years from… CONTINUE READING

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