Genetic risk factors for type 1 diabetes

  title={Genetic risk factors for type 1 diabetes},
  author={F. Pociot and {\AA}. Lernmark},
  journal={The Lancet},
  • F. Pociot, Å. Lernmark
  • Published 2016
  • Medicine
  • The Lancet
  • Type 1 diabetes is diagnosed at the end of a prodrome of β-cell autoimmunity. The disease is most likely triggered at an early age by autoantibodies primarily directed against insulin or glutamic acid decarboxylase, or both, but rarely against islet antigen-2. After the initial appearance of one of these autoantibody biomarkers, a second, third, or fourth autoantibody against either islet antigen-2 or the ZnT8 transporter might also appear. The larger the number of β-cell autoantibody types… CONTINUE READING
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