Genetic risk factors for intracranial aneurysms: a meta-analysis in more than 116,000 individuals.

@article{Alg2013GeneticRF,
  title={Genetic risk factors for intracranial aneurysms: a meta-analysis in more than 116,000 individuals.},
  author={Varinder Singh Alg and Reecha Sofat and Henry Houlden and David J Werring},
  journal={Neurology},
  year={2013},
  volume={80 23},
  pages={2154-65}
}
OBJECTIVE There is an urgent need to identify risk factors for sporadic intracranial aneurysm (IA) development and rupture. A genetic component has long been recognized, but firm conclusions have been elusive given the generally small sample sizes and lack of replication. Genome-wide association studies have overcome some limitations, but the number of robust genetic risk factors for IA remains uncertain. METHODS We conducted a comprehensive systematic review and meta-analysis of all genetic… CONTINUE READING