Genetic risk, number of previous depressive episodes, and stressful life events in predicting onset of major depression.

@article{Kendler2001GeneticRN,
  title={Genetic risk, number of previous depressive episodes, and stressful life events in predicting onset of major depression.},
  author={Kenneth S. Kendler and Laura M Thornton and Charles O. Gardner},
  journal={The American journal of psychiatry},
  year={2001},
  volume={158 4},
  pages={582-6}
}
OBJECTIVE The association between stressful life events and the onset of major depression decreases as the number of previous depressive episodes increases. How do genetic risk factors for major depression impact on this "kindling" phenomenon? In particular, do those at high genetic risk exhibit an increase in the speed of kindling, or are they "prekindled"? METHOD Using discrete-time survival analysis, the authors examined the interaction between genetic risk, number of previous depressive… CONTINUE READING
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