Genetic resistance to diet-induced obesity in chromosome substitution strains of mice

@article{Burrage2010GeneticRT,
  title={Genetic resistance to diet-induced obesity in chromosome substitution strains of mice},
  author={Lindsay C Burrage and Annie E. Baskin-Hill and David S. Sinasac and Jonathan B. Singer and Colleen M Croniger and Andrew Kirby and Edward J. Kulbokas and Mark J. Daly and Eric S. Lander and Karl W. Broman and Joseph H. Nadeau},
  journal={Mammalian Genome},
  year={2010},
  volume={21},
  pages={115-129}
}
Discovery of genes that confer resistance to diseases such as diet-induced obesity could have tremendous therapeutic impact. We previously demonstrated that the C57BL/6J-ChrA/J/NaJ panel of chromosome substitution strains (CSSs) is a unique model for studying resistance to diet-induced obesity. In the present study, three replicate CSS surveys showed remarkable consistency, with 13 A/J-derived chromosomes reproducibly conferring resistance to high-fat-diet-induced obesity. Twenty CSS… CONTINUE READING
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