Genetic rescue of nonclassical ERα signaling normalizes energy balance in obese Erα-null mutant mice.

Abstract

In addition to its role in reproduction, estradiol-17β is critical to the regulation of energy balance and body weight. Estrogen receptor α-null (Erα-/-) mutant mice develop an obese state characterized by decreased energy expenditure, decreased locomotion, increased adiposity, altered glucose homeostasis, and hyperleptinemia. Such features are reminiscent… (More)
DOI: 10.1172/JCI41702

Topics

4 Figures and Tables

Cite this paper

@article{Park2011GeneticRO, title={Genetic rescue of nonclassical ERα signaling normalizes energy balance in obese Erα-null mutant mice.}, author={Cheryl J Park and Zhen Zhao and Christine A Glidewell-Kenney and Milos Lazic and Pierre Chambon and Andr{\'e}e Krust and Jeffrey Weiss and Deborah J. Clegg and Andrea Dunaif and J. Larry Jameson and John E Levine}, journal={The Journal of clinical investigation}, year={2011}, volume={121 2}, pages={604-12} }