Genetic requirements for the survival of tubercle bacilli in primates.

@article{Dutta2010GeneticRF,
  title={Genetic requirements for the survival of tubercle bacilli in primates.},
  author={N. Dutta and S. Mehra and P. Didier and C. Roy and L. Doyle and X. Alvarez and M. Ratterree and Nicholas A. Be and G. Lamichhane and S. Jain and Michelle R. Lacey and A. Lackner and D. Kaushal},
  journal={The Journal of infectious diseases},
  year={2010},
  volume={201 11},
  pages={
          1743-52
        }
}
BACKGROUND Tuberculosis (TB) leads to the death of 1.7 million people annually. The failure of the bacille Calmette-Guérin vaccine, synergy between AIDS and TB, and the emergence of drug resistance have worsened this situation. It is imperative to delineate the mechanisms employed by Mycobacterium tuberculosis to successfully infect and persist in mammalian lungs. METHODS Nonhuman primates (NHPs) are arguably the best animal system to model critical aspects of human TB. We studied genes… Expand
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