Genetic requirements for mycobacterial survival during infection.

  title={Genetic requirements for mycobacterial survival during infection.},
  author={Christopher M. Sassetti and Eric J. Rubin},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={100 22},
Despite the importance of tuberculosis as a public health problem, we know relatively little about the molecular mechanisms used by the causative organism, Mycobacterium tuberculosis, to persist in the host. To define these mechanisms, we have mutated virtually every nonessential gene of M. tuberculosis and determined the effect disrupting each gene on the growth rate of this pathogen during infection. A total of 194 genes that are specifically required for mycobacterial growth in vivo were… CONTINUE READING
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