Genetic requirements for inheritance of RNAi in C. elegans.

  title={Genetic requirements for inheritance of RNAi in C. elegans.},
  author={Alla Grishok and Hiroaki Tabara and Craig C. Mello},
  volume={287 5462},
In Caenorhabditis elegans, the introduction of double-stranded RNA triggers sequence-specific genetic interference (RNAi) that is transmitted to offspring. The inheritance properties associated with this phenomenon were examined. Transmission of the interference effect occurred through a dominant extragenic agent. The wild-type activities of the RNAi pathway genes rde-1 and rde-4 were required for the formation of this interfering agent but were not needed for interference thereafter. In… CONTINUE READING
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