Genetic requirements for RAD51- and RAD54-independent break-induced replication repair of a chromosomal double-strand break.

@article{Signon2001GeneticRF,
  title={Genetic requirements for RAD51- and RAD54-independent break-induced replication repair of a chromosomal double-strand break.},
  author={L Signon and Anna Malkova and Maria L. Naylor and Hannah W. Klein and James E Haber},
  journal={Molecular and cellular biology},
  year={2001},
  volume={21 6},
  pages={
          2048-56
        }
}
Broken chromosomes can be repaired by several homologous recombination mechanisms, including gene conversion and break-induced replication (BIR). In Saccharomyces cerevisiae, an HO endonuclease-induced double-strand break (DSB) is normally repaired by gene conversion. Previously, we have shown that in the absence of RAD52, repair is nearly absent and diploid cells lose the broken chromosome; however, in cells lacking RAD51, gene conversion is absent but cells can repair the DSB by BIR. We now… CONTINUE READING
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