Genetic requirement for Mycl and efficacy of RNA Pol I inhibition in mouse models of small cell lung cancer.

@article{Kim2016GeneticRF,
  title={Genetic requirement for Mycl and efficacy of RNA Pol I inhibition in mouse models of small cell lung cancer.},
  author={Dong-wook Kim and Nan Wu and Young Chul Kim and Pei Cheng and Ryan S Basom and Dongkyoon Kim and Colin T Dunn and Anastasia Y Lee and Keebeom Kim and Chang Sup Lee and Andrew Singh and Adi F. Gazdar and Chris Mullins Eric Ruethling Jill Harris and Robert N. Eisenman and Kwon-Sik Park and D Macpherson},
  journal={Genes & development},
  year={2016},
  volume={30 11},
  pages={1289-99}
}
Small cell lung cancer (SCLC) is a devastating neuroendocrine carcinoma. MYCL (L-Myc) is frequently amplified in human SCLC, but its roles in SCLC progression are poorly understood. We isolated preneoplastic neuroendocrine cells from a mouse model of SCLC and found that ectopic expression of L-Myc, c-Myc, or N-Myc conferred tumor-forming capacity. We focused on L-Myc, which promoted pre-rRNA synthesis and transcriptional programs associated with ribosomal biogenesis. Deletion of Mycl in two… CONTINUE READING
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