Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs

@article{Lee2013GeneticRB,
  title={Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs},
  author={S. Lee and S. Ripke and B. Neale and S. Faraone and S. Purcell and R. Perlis and B. Mowry and A. Thapar and M. Goddard and J. Witte and D. Absher and I. Agartz and H. Akil and F. Amin and O. Andreassen and A. Anjorin and R. Anney and V. Anttila and D. Arking and P. Asherson and M. Azevedo and L. Backlund and J. Badner and A. Bailey and T. Banaschewski and J. Barchas and M. Barnes and T. Barrett and N. Bass and A. Battaglia and M. Bauer and M. Bay{\'e}s and F. Bellivier and Sarah L Bergen and W. Berrettini and C. Betancur and T. Bettecken and J. Biederman and E. Binder and D. Black and D. Blackwood and C. Bloss and M. Boehnke and D. Boomsma and G. Breen and R. Breuer and R. Bruggeman and P. Cormican and N. Buccola and J. Buitelaar and W. Bunney and J. Buxbaum and W. Byerley and E. Byrne and S. Caesar and W. Cahn and R. Cantor and M. Casas and A. Chakravarti and K. Chambert and K. Choudhury and S. Cichon and C. R. Cloninger and D. Collier and E. Cook and H. Coon and B. Cormand and A. Corvin and W. Coryell and D. Craig and I. Craig and J. Crosbie and M. Cuccaro and D. Curtis and D. Czamara and S. Datta and G. Dawson and Richard O. Day and E. D. de Geus and F. Degenhardt and S. Djurovic and G. Donohoe and A. Doyle and J. Duan and F. Dudbridge and E. Duketis and R. Ebstein and H. Edenberg and J. Elia and S. Ennis and B. {\'E}tain and A. Fanous and A. Farmer and I. Ferrier and M. Flickinger and E. Fombonne and T. Foroud and J. Frank and B. Franke and C. Fraser and R. Freedman and N. Freimer and C. Freitag and M. Friedl and L. Fris{\'e}n and L. Gallagher and P. Gejman and L. Georgieva and E. Gershon and D. Geschwind and I. Giegling and M. Gill and S. Gordon and K. Gordon-Smith and E. Green and T. Greenwood and D. Grice and M. Gross and D. Grozeva and W. Guan and H. Gurling and L. de Haan and J. Haines and H. Hakonarson and J. Hallmayer and S. Hamilton and M. Hamshere and T. Hansen and A. Hartmann and M. Hautzinger and A. Heath and A. Henders and S. Herms and I. Hickie and M. Hipolito and S. Hoefels and P. Holmans and F. Holsboer and W. Hoogendijk and J. Hottenga and C. Hultman and Vanessa Hus and A. Ingason and M. Ising and S. Jamain and E. G. Jones and Ian Jones and L. Jones and J. Tzeng and A. K{\"a}hler and R. Kahn and R. Kandaswamy and M. Keller and J. Kennedy and E. Kenny and L. Kent and Y. Kim and G. Kirov and S. Klauck and L. Klei and J. Knowles and M. Kohli and D. Koller and B. Konte and A. Korszun and L. Krabbendam and Robert Krasucki and J. Kuntsi and Phoenix Kwan and M. Land{\'e}n and N. L{\aa}ngstr{\"o}m and M. Lathrop and J. Lawrence and W. Lawson and M. Leboyer and D. Ledbetter and P. Lee and T. Lencz and K. Lesch and D. Levinson and C. Lewis and J. Li and P. Lichtenstein and J. Lieberman and D. Lin and D. Linszen and C. Liu and F. Lohoff and S. Loo and C. Lord and J. Lowe and S. Lucae and D. Macintyre and P. Madden and E. Maestrini and P. Magnusson and Pamela B. Mahon and W. Maier and A. Malhotra and S. Mane and C. Martin and N. Martin and M. Mattheisen and K. Matthews and M. Mattingsdal and S. McCarroll and K. McGhee and J. McGough and P. McGrath and P. McGuffin and M. McInnis and A. McIntosh and R. McKinney and A. McLean and F. McMahon and W. McMahon and A. McQuillin and H. Medeiros and S. Medland and S. Meier and I. Melle and F. Meng and J. Meyer and C. Middeldorp and L. Middleton and V. Milanova and A. Miranda and A. Monaco and G. Montgomery and J. Moran and D. Moreno-De-Luca and G. Morken and D. Morris and E. Morrow and V. Moskvina and P. Muglia and T. M{\"u}hleisen and W. Muir and B. M{\"u}ller-Myhsok and M. Murtha and R. Myers and I. Myin-Germeys and M. Neale and S. Nelson and C. Nievergelt and I. Nikolov and V. Nimgaonkar and W. Nolen and M. N{\"o}then and J. Nurnberger and E. Nwulia and D. Nyholt and C. O'Dushlaine and R. Oades and A. Olincy and G. Oliveira and L. Olsen and R. Ophoff and U. Osby and M. Owen and A. Palotie and J. Parr and A. Paterson and C. Pato and M. Pato and B. Penninx and M. Pergadia and M. Pericak-Vance and B. Pickard and J. Pimm and J. Piven and D. Posthuma and J. Potash and F. Poustka and P. Propping and V. Puri and D. Quested and E. Quinn and J. Ramos-Quiroga and H. Rasmussen and S. Raychaudhuri and K. Rehnstr{\"o}m and A. Reif and M. Ribas{\'e}s and J. Rice and M. Rietschel and K. Roeder and H. Roeyers and L. Rossin and A. Rothenberger and G. Rouleau and D. Ruderfer and D. Rujescu and A. Sanders and S. Sanders and S. Santangelo and J. Sergeant and R. Schachar and M. Schalling and A. Schatzberg and W. Scheftner and G. Schellenberg and S. Scherer and N. Schork and T. Schulze and J. Schumacher and M. Schwarz and E. Scolnick and L. Scott and J. Shi and Paul D. Shilling and S. Shyn and J. Silverman and S. Slager and S. Smalley and J. Smit and E. Smith and E. Sonuga-Barke and D. St Clair and M. State and M. Steffens and H. Steinhausen and J. Strauss and J. Strohmaier and T. Stroup and J. Sutcliffe and P. Szatmari and Szabocls Szelinger and S. Thirumalai and R. Thompson and A. Todorov and F. Tozzi and J. Treutlein and M. Uhr and E. J. van den Oord and G. van Grootheest and J. van os and A. Vicente and V. Vieland and J. Vincent and P. Visscher and C. Walsh and T. Wassink and S. Watson and M. Weissman and T. Werge and T. Wienker and E. Wijsman and G. Willemsen and N. Williams and A. Willsey and S. Witt and W. Xu and A. Young and T. Yu and S. Zammit and P. Zandi and Peng Zhang and F. Zitman and S. Z{\"o}llner and B. Devlin and J. Kelsoe and P. Sklar and M. Daly and M. O’Donovan and N. Craddock and P. Sullivan and J. Smoller and K. Kendler and N. Wray},
  journal={Nature Genetics},
  year={2013},
  volume={45},
  pages={984-994}
}
Most psychiatric disorders are moderately to highly heritable. [...] Key Method To examine shared genetic etiology, we use genome-wide genotype data from the Psychiatric Genomics Consortium (PGC) for cases and controls in schizophrenia, bipolar disorder, major depressive disorder, autism spectrum disorders (ASD) and attention-deficit/hyperactivity disorder (ADHD). We apply univariate and bivariate methods for the estimation of genetic variation within and covariation between disorders. SNPs explained 17–29% of…Expand
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