• DOI:10.1101/309559
Corpus ID: 196633835

Genetic regulatory mechanisms of smooth muscle cells map to coronary artery disease risk loci

@article{Liu2018GeneticRM,
  title={Genetic regulatory mechanisms of smooth muscle cells map to coronary artery disease risk loci},
  author={B. Liu and M. Pjanic and T. Wang and T. Nguyen and M. Gloudemans and A. Rao and Victor G. Castano and Sylvia T Nurnberg and D. Rader and S. Elwyn and E. Ingelsson and S. Montgomery and Clint L. Miller and T. Quertermous},
  journal={bioRxiv},
  year={2018}
}

B. Liu, M. Pjanic, +11 authors T. Quertermous

Published 2018

Biology

bioRxiv

Coronary artery disease (CAD) is the leading cause of death globally. Genome-wide association studies (GWAS) have identified more than 95 independent loci that influence CAD risk, most of which reside in non-coding regions of the genome. To interpret these loci, we generated transcriptome and whole-genome datasets using human coronary artery smooth muscle cells (HCASMC) from 52 unrelated donors, as well as epigenomic datasets using ATAC-seq on a subset of 8 donors. Through systematic comparison… CONTINUE READING

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