Genetic regulation on ex vivo differentiated natural killer cells from human umbilical cord blood CD34+ cells.

@article{Pinho2012GeneticRO,
  title={Genetic regulation on ex vivo differentiated natural killer cells from human umbilical cord blood CD34+ cells.},
  author={Maria Jo{\~a}o Pinho and C Joana Marques and Filipa Abreu Gomes de Carvalho and Michael Punzel and M{\'a}rio Sousa and Alberto Barros},
  journal={Journal of receptor and signal transduction research},
  year={2012},
  volume={32 5},
  pages={238-49}
}
Natural killer (NK)-cells are a lymphocyte population playing a critical role in the immune surveillance against tumors and virally infected cells. The development of human hematopoietic stem cells (hHSC) into fully differentiated NK-cells pass through discrete stages of differentiation involving a variety of factors such as cytokines, membrane factors, and transcription factors (TFs). Because there is lack of studies in this field, we decided to perform an extended analysis of TFs during in… CONTINUE READING
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