Genetic regulation of stem cell origins in the mouse embryo

  title={Genetic regulation of stem cell origins in the mouse embryo},
  author={Amy Ralston and Janet Rossant},
  journal={Clinical Genetics},
‘Stem cell’ has practically become a household term, but what is a stem cell and where does it come from? Insight into these questions has come from the early mouse embryo, or blastocyst, from which three kinds of stem cells have been derived: embryonic stem (ES) cells, trophoblast stem (TS) cells, and extraembryonic endoderm (XEN) cells. These stem cells appear to derive from three distinct tissue lineages within the blastocyst: the epiblast, the trophectoderm, and the extraembryonic endoderm… 
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