• Biology
  • Published 1999

Genetic regulation of contingent macrophage- and T-cell-dependent steps in islet inflammation

@inproceedings{Fox1999GeneticRO,
  title={Genetic regulation of contingent macrophage- and T-cell-dependent steps in islet inflammation},
  author={Casey J. Fox},
  year={1999}
}
Insulin dependent diabetes rneliitus (IDDM) is a complex disease that is conferred by at least nineteen susceptibility genes (Iddl 19) in the nonobese, diabetic (NOD) mouse, of which only Iddl has been identified. Although NOD and nonobese, diabetes resistant (NOR) mice are 8 8 8 genetically-identical. C57BLKS/J-denved aileles at Idd4, 5, 9, 11 and 13 protect NOR animds from destructive islet inflammation. In an effort to define immunotherapeutic targets in high risk individuals, our major… CONTINUE READING

Figures and Tables from this paper.