Genetic regulation of bone mineral density in mice.

  title={Genetic regulation of bone mineral density in mice.},
  author={Robert F. Klein},
  journal={Journal of musculoskeletal & neuronal interactions},
  volume={2 3},
Peak bone mass is a major determinant of risk of osteoporotic fracture. Family and twin studies have found a strong genetic component to the determination of bone mineral density (BMD). However, BMD is a complex trait whose expression is confounded by environmental influences and polygenic inheritance. The number, locations and effects of the individual genes contributing to natural variation in this trait are all unknown. The extreme difficulty of dissecting out environmental factors from… CONTINUE READING


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Identification of chromosomal loci influencing peak bone mass in mice

  • RF Klein, AS Carlos, +5 authors ES. Orwoll
  • J Bone Miner Res
  • 2001

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