Genetic regulation of T regulatory, CD4, and CD8 cell numbers by the arthritis severity loci Cia5a, Cia5d, and the MHC/Cia1 in the rat.

@article{Brenner2007GeneticRO,
  title={Genetic regulation of T regulatory, CD4, and CD8 cell numbers by the arthritis severity loci Cia5a, Cia5d, and the MHC/Cia1 in the rat.},
  author={Max Brenner and Teresina Laragione and Nuriza C. Yarlett and P{\'e}rcio Saltz Gulko},
  journal={Molecular medicine},
  year={2007},
  volume={13 5-6},
  pages={
          277-87
        }
}
T cells have a central role in the pathogenesis of autoimmune arthritis, and several abnormalities in T cell homeostasis have been described in rheumatoid arthritis (RA). We hypothesized that T cell phenotypes, including frequencies of different subsets of T regulatory (Treg) cells and in vitro functional responses could be genetically determined. Furthermore, we considered that the genetic contribution would be accounted for by one of the arthritis regulatory quantitative trait loci (QTL… CONTINUE READING
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