Genetic properties for the suppression of development of putative preneoplastic glutathione S-transferase placental form-positive foci in the liver of carcinogen-resistant DRH strain rats.

@article{Denda1999GeneticPF,
  title={Genetic properties for the suppression of development of putative preneoplastic glutathione S-transferase placental form-positive foci in the liver of carcinogen-resistant DRH strain rats.},
  author={Ayumi Denda and Wakashi Kitayama and Yoichi Konishi and Y Yan and Yasushi Fukamachi and Masayoshi Miura and Sadao Gotoh and Kunio Ikemura and Toshihiro Abe and Taneaki Higashi and Ken Higashi},
  journal={Cancer letters},
  year={1999},
  volume={140 1-2},
  pages={59-67}
}
The post-initiation stage of hepatocarcinogenesis was investigated in carcinogen-resistant inbred DRH rats and the parental strain, carcinogen-sensitive Donryu rats. Male rats at 5 weeks of age from both strains were treated with N-nitrosodiethylamine (200 mg/kg i.p.) followed by feeding with a diet containing 3'-methyl-4-dimethylaminoazobenzene (3'-Me-DAB) from 2 weeks later and were then subjected to partial hepatectomy at 1 week later. At 8 weeks after the start of treatment, the mean area… CONTINUE READING